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ORIGINAL ARTICLE
Year : 2016  |  Volume : 22  |  Issue : 3  |  Page : 288--294

Factors influencing compliance to radical treatment of middle thoracic esophageal cancer: An audit from a regional cancer centre

Rakesh Kapoor, Anshuma Bansal, Shikhar Kumar, Ravi Teja Miriyala 
 Department of Radiotherapy, PGIMER, Chandigarh, India

Correspondence Address:
Anshuma Bansal
Department of Radiotherapy, PGIMER, Chandigarh
India

Background: The aim of this study is to identify the factors responsible for interruption of planned treatment in patients of carcinoma mid-thoracic esophagus and also discuss the strategies for improving treatment completion rates. Materials and Methods: Patients with nonmetastatic mid-thoracic esophageal cancer who received treatment by multimodality approach using chemotherapy, radiation, and/or surgery were retrospectively analyzed. Factors influencing compliance with planned treatment completion were evaluated, and their significance was determined using multivariate Cox regression analysis. Results: Ninety-one patients were reviewed. Median follow-up period was 11 months. Of 15 patients planned with neoadjuvant chemoradiation followed by surgery (Group 1), only 6 (40%) could complete the treatment. Similarly, only 19 out of 36 patients (52.8%) completed the planned definitive chemoradiation (Group 2). Furthermore, of forty patients planned with definitive radiotherapy (Group 3), 29 patients only (72.5%) completed this schedule. The rate of completion of therapy was worst in Group 1. The most common reason for noncompletion of planned treatment was nutritional inadequacy and excessive weight loss in all groups. In addition, chemotherapy-induced myelosuppression (P = 0.05) was the factor leading to treatment interruption in Group 2 and radiation-induced acute mucositis (P = 0.02) and lost to follow-up (P = 0.02) were the factors in Group 3. Conclusions: Rate of treatment completion significantly impacts survival rates. Nutritional inadequacy was the most common factor for noncompletion of planned treatment. A well-trained management team consisting of oncologist, dietitian, and psychotherapist can help overcome these factors and thereby improve the treatment completion rates.


How to cite this article:
Kapoor R, Bansal A, Kumar S, Miriyala RT. Factors influencing compliance to radical treatment of middle thoracic esophageal cancer: An audit from a regional cancer centre.Indian J Palliat Care 2016;22:288-294


How to cite this URL:
Kapoor R, Bansal A, Kumar S, Miriyala RT. Factors influencing compliance to radical treatment of middle thoracic esophageal cancer: An audit from a regional cancer centre. Indian J Palliat Care [serial online] 2016 [cited 2021 May 18 ];22:288-294
Available from: https://www.jpalliativecare.com/article.asp?issn=0973-1075;year=2016;volume=22;issue=3;spage=288;epage=294;aulast=Kapoor;type=0