Indian Journal of Palliative Care
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Year : 2020  |  Volume : 26  |  Issue : 3  |  Page : 348--351

Impact of radiation therapy on pain relief of cancer patients affected by on malignant psoas syndrome: 26 years of experience

1 Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41500, Larisa, Greece
2 Department of Radiation Oncology, General Anti-Cancer Hospital Saint Savvas, 171 Alexandras Avenue, 115 22, Athens, Greece
3 Department of Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy
4 First Department of Radiology, Radiotherapy Unit, Aretaieion University Hospital, Medical School of Athens, Athens, Greece
5 Department of Radiation Oncology, Jordanian Royal Medical Services, King Hussein Medical Center, King Abdullah II St 230, Amman, Jordan
6 Department of Oncology, Veterans Hospital (NIMTS), 10-12 Monis Petraki Str, 115 21, Athens, Greece
7 Oncology Clinic, H. Dunant Hospital, 107 Mesogeion Av, Athens, Greece
8 Department of Radiation Oncology, University Hospital of Larissa, Biopolis, 41500, Larisa, Greece
9 Department of Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41500, Larisa, Greece
10 Department of Radiation Oncology, Groupe Hospitalier Intercommunal Le Raincy, Montfermeil, 10 Rue du Général Leclerc, 93370 Montfermeil, France

Correspondence Address:
Alexandros Gerontopoulos
Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPC.IJPC_205_19

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Aim: The malignant psoas syndrome (MPS) is a rare and complex cancer-related clinical entity, with a significant impact on cancer patients' quality of life. The literature describing malignant infiltration of the psoas muscle as well as its management is limited. The primary endpoint of the study was the assessment of pain relief in symptomatic terminal-stage MPS patients. Materials and Methods: Patients underwent hypofractionated (two- or three-dimensional conformal) radiotherapy as palliative treatment. A dose of 42.5 Gy in 17 daily fractions (2.5 Gy/fraction) was prescribed. Pain response was measured before 3 and 6 months after radiation delivery. Results: Between May 1992 and April 2019, eight patients were treated. The median age was 75 years (range: 59–87 years). All patients had distant metastatic disease at the time of treatment. We found a significant pain relief (median duration of response of 105 days) and an improvement in health-related quality of life. Conclusions: Radiotherapy had a favorable outcome and can be considered an effective analgesic treatment in case of painful MPS.


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