Indian Journal of Palliative Care
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Year : 2018  |  Volume : 24  |  Issue : 2  |  Page : 184--188

Prognostic factors of malignant pleural effusion among palliative care outpatients: A retrospective study

1 Department of Medical Oncology, Christian Medical College Hospital, Alleppey, Kerala, India
2 Department of Radiation Oncology, Prathyasa Cancer Hospital, Alleppey, Kerala, India
3 Department of Pulmonary Medicine, Palliative Care Unit, Vellore, Tamil Nadu, India
4 Department of Radiotherapy, Palliative Care Unit, Vellore, Tamil Nadu, India
5 Department of Biostatistics, Christian Medical College Hospital, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. Jenifer Jeba
Department of Medical Oncology, Christian Medical College Hospital, Vellore - 632 004, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPC.IJPC_183_17

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Background: Malignant pleural effusion (MPE) has varied survival and indicates advanced disease. LENT prognostic score is the first validated score used for MPE. This study assessed the role of LENT among palliative care cancer patients and assessed different patient, tumor, and treatment related factors that may affect survival. Methods: A retrospective study of advanced cancer patients with MPE, seen in palliative care outpatient clinic (2013–2015) until death, was done. LENT prognostic score could be calculated in 15 patients. Patient, tumor, and treatment related factors that affect survival were assessed. Results: The study included 48 patients (70.8% female; 29.2% male) with a median age of 53 years. Lung (41.7%) was the most common primary, and adenocarcinoma (44.7%) was the most common histology. The median overall survival (OS) was 14.5 months (interquartile range [IQR]: 5.25–32.75) and median survival time (ST) was 3 months (IQR: 1–7.75). ST was significantly low with poor Eastern Cooperative Oncology Group (ECOG) performance status (P = 0.002), bilateral effusion (P < 0.001), and with no oncological treatment after MPE diagnosis (P < 0.001). OS and ST were significantly low with lung primary (P = 0.006 and 0.02, respectively). Age, gender, breathlessness, tumor histology, lung metastasis, and interventions for MPE did not significantly affect survival. The median ST in the moderate and high risk LENT groups was 6 and 3 months, respectively (P = 0.16). Conclusion: ECOG performance status, bilateral effusion, and no oncological treatment after diagnosis of MPE were associated with poor ST. Lung primary was associated with shorter OS and ST. Small numbers precluded any definitive conclusion on the prognostic value of LENT in our group of patients, and hence larger studies are recommended.


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