Indian Journal of Palliative Care
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Year : 2016  |  Volume : 22  |  Issue : 1  |  Page : 101--103

Pregabalin in chemotherapy induced neuropathic pain

Department of Palliative Care and Psychooncology, Tata Medical Center, Kolkata, West Bengal, India

Correspondence Address:
Shrikant Atreya
Department of Palliative Care and Psychooncology, Tata Medical Center, Kolkata, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1075.173941

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Chemotherapeutic agents belonging to vinca alkaloids, taxanes, and antitubulins produce peripheral neuropathy for which there is no validated treatment. Pregabalin, a gamma-aminobutyric acid analog, is known to inhibit theα2δ subunit of the voltage-gated calcium channel. Earlier studies and case reports have shown pregabalin to be effective in treating neuropathic pain. We present a case series of patients with chemotherapy-induced peripheral neuropathy who were successfully treated with pregabalin with reduction in the hyperalgesia, allodynia, and improvement in the quality of life.


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Online since 1st October '05
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