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ORIGINAL ARTICLE
Year : 2015  |  Volume : 21  |  Issue : 3  |  Page : 311--316

Is Karnofsky performance status correlate with better overall survival in palliative conformal whole brain radiotherapy? Our experience

Alessia Reali, Simona Allis, Andrea Girardi, Roberta Verna, Lavinia Bianco, Maria Grazia Ruo Redda 
 Department of Oncology, Radiation Oncology Unit, University of Turin, S. Luigi Hospital, Orbassano, Italy

Correspondence Address:
Maria Grazia Ruo Redda
Department of Oncology, Radiation Oncology Unit, University of Turin, S. Luigi Hospital, Orbassano
Italy

Aim: Brain metastases (BMs) are a common event in the progression of many human cancers. The aim of this study was to evaluate the potential prognostic factors for the clinical identification of a subgroup of patients that could benefit from whole brain conformal radiotherapy (WBRT). Materials and Methods: From January 2010 to February 2014, 80 patients with a diagnosis of BMs underwent WBRT at our Radiation Oncology Department, San Luigi Hospital, Italy. Among them, 36 medical records were retrospective reviewed. Gender, age, Karnofsky performance status (KPS), number of BMs on computed tomography and/or magnetic resonance images, presence or absence of perilesional edema, presence or absence of necrosis pattern, and histology of primary tumor were analyzed. Univariate and multivariate analyses were performed. Results: In our cohort of patients, significant prognostic factors for 20 months overall survival was KPS> 70, while a statistical trend (P = 0.098) was registered regarding primary breast. Conclusion: WBRT can be still considered a standard and effective treatment in patients with BMs. High KPS and breast cancer primary tumor seem to be useful parameters for characterize a subgroup of patients with more favorable prognosis.


How to cite this article:
Reali A, Allis S, Girardi A, Verna R, Bianco L, Redda MG. Is Karnofsky performance status correlate with better overall survival in palliative conformal whole brain radiotherapy? Our experience.Indian J Palliat Care 2015;21:311-316


How to cite this URL:
Reali A, Allis S, Girardi A, Verna R, Bianco L, Redda MG. Is Karnofsky performance status correlate with better overall survival in palliative conformal whole brain radiotherapy? Our experience. Indian J Palliat Care [serial online] 2015 [cited 2019 Nov 18 ];21:311-316
Available from: http://www.jpalliativecare.com/article.asp?issn=0973-1075;year=2015;volume=21;issue=3;spage=311;epage=316;aulast=Reali;type=0