Indian Journal of Palliative Care
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 » Introduction
 » Methods
 » Results
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Table of Contents 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 26  |  Issue : 3  |  Page : 271-275

Effectiveness of a breathing training program on quality of life in patients with predialysis chronic kidney disease: A randomized controlled trial


1 Department of Nursing, National Institute of Nursing Education, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Submission11-Jul-2019
Date of Decision02-Nov-2019
Date of Acceptance31-Dec-2019
Date of Web Publication29-Aug-2020

Correspondence Address:
Lasara Kharbteng
National Institute of Nursing Education, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPC.IJPC_118_19

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 » Abstract 


Context: Chronic kidney disease (CKD) patients have suboptimal quality of life (QOL). Various studies/researches have revealed that breathing exercises have a positive and favorable impact on different systems of the body. Aims: This study aims to assess the effect of a breathing training program on QOL in patients with predialysis CKD. Settings: The study was a single-center study conducted at PGIMER, Chandigarh. Design: Randomized controlled trial. Methods: Sixty individuals were enrolled and randomized using lottery method. QOL was assessed or evaluated by Kidney Disease and QOL questionnaire (KDQOL™-36). Breathing exercises were taught to the intervention group. Patients included in control group continued with the routine care. Assessment of QOL was done after 4 weeks in both the groups. Results: Change in KDQOL™-36 scores showed significant difference between control and the intervention group. The mean scores of control group in the subscale effects of kidney disease, SF-12 Physical functioning (Physical Health Composite) and SF-12 Mental functioning (Mental Health Composite) were 84.79, 39.16 and 37.40, respectively, whereas in intervention group, the respective mean scores were 91.88, 43.92, and 44.16. The difference was statistically significant (P = 0.04, P = 0.01, and P = 0.003, respectively). Conclusions: Breathing training program improves QOL in patients with predialysis CKD.


Keywords: Breathing training program, chronic kidney disease, quality of life


How to cite this article:
Kharbteng L, Monaliza, Kumar V, Kaur S, Ghai S. Effectiveness of a breathing training program on quality of life in patients with predialysis chronic kidney disease: A randomized controlled trial. Indian J Palliat Care 2020;26:271-5

How to cite this URL:
Kharbteng L, Monaliza, Kumar V, Kaur S, Ghai S. Effectiveness of a breathing training program on quality of life in patients with predialysis chronic kidney disease: A randomized controlled trial. Indian J Palliat Care [serial online] 2020 [cited 2020 Sep 21];26:271-5. Available from: http://www.jpalliativecare.com/text.asp?2020/26/3/271/293855





 » Introduction Top


Chronic kidney disease (CKD) is a rapidly increasing illness with high rate of morbidity and mortality. The prognosis is generally poor with worsening of physical functioning leading to psychological distress.[1] CKD patients have suboptimal quality of life (QOL) in comparison with normal general population.[2] In all stages of kidney disease, QOL is decreased.[3] An important aspect of health and well-being is QOL. Effectiveness of any treatment is determined by QOL. Since chronic diseases are immedicable, the target is to better the health of patients.[4],[5],[6]

Previous conducted studies/researches have revealed that exercises involving breathing have beneficial results on different systems of the human body.[7],[8],[9],[10],[11],[12],[13],[14],[15],[16] Breathing exercises can improve the prognosis of CKD. Since beneficial effects of breathing exercises were found in chronically ill patients in other population, there was a probability for a similar study in patients suffering from CKD. The study was aimed to determine if breathing training program is beneficial to enhance the QOL of CKD patients. The objective was to assess/evaluate the effectiveness of a breathing training program on QOL in patients with predialysis CKD.


 » Methods Top


A randomized controlled trial was carried out at PGIMER, Chandigarh. In the study, predialysis CKD patients between the age group of 18–65 years, who have clinically stable course for last 1 month and estimated glomerular filtration rate between 15 and 45 ml/min/1.73 m 2 were included. Those on dialysis, pregnant or lactating females were excluded. Using lottery method, randomization into intervention and control group was done. Individuals were interviewed using pro forma containing socio demographic variables and clinical profile. Assessment of QOL was assessed in both experimental and control group by using Kidney Disease and QOL questionnaire (KDQOL™-36) at baseline and after 4 weeks in both the group.

Intervention: Breathing training program consisting of three breathing exercises, i.e. Alternate nostril breathing or anulom-vilom, 4-7-8 breathing exercise and breath counting.[17],[18] It was taught with the help of a video and demonstration to the individuals in the intervention group individually.

The first practice session of the breathing exercises was demonstrated by the researcher. The individuals were then asked to perform return demonstration which was evaluated by the researcher for correct technique. The individuals in the experimental group were handed over a prerecorded video to practice the exercises at home. The individuals were asked to perform breathing exercises at home for 5 min three times a day daily.

  • Frequency – thrice daily
  • Number of sessions – three times a day for 4 weeks, i.e., total 90 sessions
  • How long each session – 5 min
  • Total intervention – 4 weeks' intervention period with total 15 min/day.


The video acted as a reminder and reference to the patients about the steps to be followed. A daily record sheet was given to the individuals to record daily the date and time of performing the breathing exercises.

Follow-up was done via phone calls made by the researcher (every 7th day) to the individuals to ensure that they are doing the breathing exercises. The control group received routine care. Assessment of QOL was done after 4 weeks in both the groups by the same researcher.

Outcome and outcome measures

Quality of life

Change in the KDQOL score as measured or assessed by KDQOL™-36.

KDQOL™-36 is a standardized tool. It is a public document available without charge. It is a kidney disease-specific measure of health related QOL (HRQOL). This instrument consists of 36 items or questions, divided in two components: one general component, including 12 QOL questions based on the SF-12 (short version of the SF-36), and a specific 24-question component about the kidney disease. At the same time, each item or question is regrouped in five subscales or domains, where the general component groups the SF-12 subscale Physical health composite (questions 1–12) and SF-12 subscale Mental health composite (questions 1–12) while the specific component groups the subscales Burden of Kidney Disease (questions 13–16), Symptoms and Problems (questions 17–28) and Effects of Kidney Disease on Daily Life (questions 29–36).

Scores of the different subscales were calculated according to Kidney Disease QOL (KDQOL™-36) scoring program. Raw precoded numeric values for each item were transformed linearly to a 0–100 range, with higher scores reflecting better QOL. Item scores range from 0 to 100, with 0 indicating the worst and 100 the best QOL.

Each item was put on a 0–100 range so that the lowest and highest possible scores are set at 0 and 100, respectively. Scores represent the percentage of total possible score achieved. It includes averaging items in each scale together.

Statistical considerations

To check the feasibility of the intervention and for sample size calculation, we conducted a pilot study in June 2016. Sample size was calculated according to the effect size determined in the pilot study. The result of the calculated effect size indicated that a total of 52 individuals (26 in each group) were required with 80% power at a significance level of 5%. For the present study, we recruited 62 individuals (31 in each group). Collected data was entered in IBM SPSS (Statistical Package for Social Science) Statistics version 20 (IBM Corp., Armonk, NY, USA) for descriptive and inferential analysis. QOL scores were calculated according to KDQOL™-36 scoring program. P ≤ 0.05 was considered as statistically significant.

Ethical clearance was obtained from the Institution Ethical Committee. All the study participants gave their consent to participate in the study. They were assured of the confidentiality of the information. Registration of the study was done under the Clinical Trials Registry-India (CTRI/2017/07/008973).


 » Results Top


Participants were recruited between July and October, 2016. Among 77 individuals screened, 15 individuals were excluded because they did not meet eligibility criteria [Figure 1]. Sixty-two patients were enrolled and randomized using lottery method into intervention and control group. One subject from each group was lost to follow-up. Analysis was done only for the 60 individuals who completed the posttest questionnaires. The dialysis-specific component was excluded because only predialysis patients were included.
Figure 1: Consort diagram

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Mean age was 51.83 ± 10.27 years in control and 52.06 ± 6.97 years in intervention group. 70% were males in control and 50% were males in intervention group. In [Table 1], the baseline sociodemographic and clinical profile of the individuals are mentioned. Both the groups were comparable as per P > 0.05. Change in KDQOL™-36 scores for the subscales symptom/problem list and SF-12 physical health composite showed significant difference in mean score in the group receiving intervention. No significant difference was observed in mean score in the control group post intervention [Table 2]. KDQOL™-36 scores for the subscales-effects of kidney disease, symptom/problem list and burden of kidney disease were comparable at baseline [Table 3]. The t-test analyses revealed that the score changes were significantly greater in the group receiving intervention than in the control group in the subscale effects of kidney disease (P = 0.04), SF-12 physical functioning or physical health component (P = 0.01) and SF-12 mental functioning or mental health composite (P = 0.003).
Table 1: Sociodemographic and clinical profile of the individuals in both the groups (n=60)

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Table 2: Quality of life of the individuals as per kidney disease and quality of life questionnaire™ -36 (n=60)

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Table 3: Comparison of quality of life of the individuals as per kidney disease and quality of life questionnaire™ -36 in both the groups pre- and post-intervention (n=60)

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 » Discussion Top


In the present randomized trial, we evaluated the effectiveness of a breathing training program on QOL in patients with pre-dialysis CKD. The breathing training program administered to pre-dialysis CKD patients showed significant improvement in patients' KDQOL™-36 scores in the intervention group.

The findings of the present study are supported by observation of studies reported earlier. It was stated by Pal et al.[7] that a brief time of breathing induces a reaction of relaxation, indicating a decrease in sympathetic nervous system activity, reduces the result of strain as well as stress on the human body, boosts cardiovascular as well as respiratory functions, improves the physical and mental health. Tsai et al.[8] showed that there is significant improvement in the mental component summary and the role emotional domain in hemodialysis patients in the breathing training group. Malathi [9] revealed significant increase in the QOL amidst patients suffering from COPD with breathing training program. Yoyok et al.[10] showed that breathing exercise which is done on a regular basis increase the secretion of IgG, endorphins and decrease blood glucose. Silva et al.[11] stated that practicing deep breathing exercises significantly decreased the diastolic blood pressure and anxiety level in patients with Coronary Artery Disease. It was also found that yoga breathing improve mental QOL, sleep and reduces anxiety among patients with cancer.[12] In another study, there is reduction in anxiety, pain, fatigue and insomnia in patients on hemodialysis.[13] Vitality and mental health scores of patients with obstructive sleep apnea improved with relaxation breathing training.[14] A scrutiny of researches of patients with asthma showed that QOL improved after they were taught and performed diaphragmatic breathing.[15] Other studies have shown that breathing leads to relaxation. They help to promote relaxation, inner peace and calmness while reducing stress, agitation and anxiety. The regular practice of breathing exercise decreases strain and stress on the human body, betters physical and mental health.[16]

In present study, the mean age was 52.06 ± 6.97 years in the intervention and 51.83 ± 10.27 years in the control group. Most participants were males, married, Hindu by religion and educated up to secondary level. Similar finding were reported by Guerra-Guerrero et al.[19] and Kim et al.[20] The most common co-morbidity was hypertension (HTN) followed by diabetes. Hypertension being most common co morbidity could be due to the deterioration in kidney function leading to hypertension. This finding was in contrast to Kim et al.[20] where diabetes was the most common followed by HTN.

Our results indicate that breathing training program can be successful in upgrading QOL of patients. This intervention helps in promoting relaxation to the body and mind, it provides a feeling of well-being, improves the normal physiological function of the body thus improving physical and mental health. The benefits of breathing exercises are well worth the effort and a person is less prone to health issues.

Breathing training program can be voluntarily incorporated by nurses into the charge of such suffering patients. Furthermore, this intervention can be a beneficial aid that any nurse or caregiver might utilize for the betterment of other patients. This intervention seems to give nurses a pathway to offer support to a vulnerable population. Nurses can promote QOL through patient education and planning programs such as breathing training programs.

Limitations of the study: Long term or continuing follow up is required to see total impact of breathing training program on QOL. The duration of the data collection was limited, therefore, generalization cannot be made from the findings out of the small study sample.


 » Conclusions Top


The study was aimed to assess or evaluate the effectiveness of a breathing training program on QOL in patients with predialysis CKD. The study showed that as per KDQOL™-36, significant difference was noted between the intervention and control group. It is concluded that breathing training program is significantly effective in improving QOL in CKD patients.

Acknowledgment

The authors acknowledge Ms Geetanjali Loomba, MSc Nursing (Medical Surgical Nursing), National Institute of Nursing Education, PGIMER and Mr Abhijeet Singh, Clinical Photographer from Department of Photography, PGIMER, Chandigarh for their involvement in making the video.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
 » References Top

1.
Black JM, Hawks JH. Management of clients with renal disorders. In: Medical Surgical Nursing-Clinical Management for Positive Outcomes. 8th ed. St. Louis: Elsevier India Private Limited; 2009. p. 796-9.  Back to cited text no. 1
    
2.
Gudex CM. Health-related quality of life in endstage renal failure. Qual Life Res 1995;4:359-66.  Back to cited text no. 2
    
3.
Cruz MC, Andrade C, Urrutia M, Draibe S, Nogueira-Martins LA, Sesso Rde C, et al. Quality of life in patients with chronic kidney disease. Clinics (Sao Paulo) 2011;66:991-5.  Back to cited text no. 3
    
4.
Saban KL, Stroupe KT, Bryant FB, Reda DJ, Browning MM, Hynes DM, et al. Comparison of health-related quality of life measures for chronic renal failure: Quality of well-being scale, short-form-6D, and the kidney disease quality of life instrument. Qual Life Res 2008;17:1103-15.  Back to cited text no. 4
    
5.
Schatell D, Witten B. Measuring Dialysis Patients' Health Related Quality of Life with the KDQOL-36TM; April, 2012. Available from: http://www.kdqol-complete.org. [Last accessed on 2017 Mar 29].  Back to cited text no. 5
    
6.
Shdalfat E, Mohd R. Quality of life of caregivers and patients undergoing haemodialysis at ministry of health, Jordan. Int J Appl Sci Technol 2012;2:75-85. Available from: http://www.ijastnet.com/journals/vol_2 No_3 March_2012/8.pdf. [Last accessed on 2015 Jan 09].  Back to cited text no. 6
    
7.
Pal GK, Velkumary S, Madanmohan. Effect of short-term practice of breathing exercises on autonomic functions in normal human volunteers. Indian J Med Res 2004;120:115-21.  Back to cited text no. 7
    
8.
Tsai SH, Wang MY, Miao NF, Chian PC, Chen TH, Tsai PS, et al. CE: Original research: The efficacy of a nurse-led breathing training program in reducing depressive symptoms in patients on hemodialysis: A randomized controlled trial. Am J Nurs 2015;115:24-32.  Back to cited text no. 8
    
9.
Malathi G. Quasi experimental study to assess the effectiveness of selected nursing interventions on health related quality of life and activities of daily living among COPD patients in selected tertiary hospital. IOSR J Nurs Health Sci 2015;4:19-23. Available from: http://www.iosrjournals.org. [Last accessed on 2015 Jan 07].  Back to cited text no. 9
    
10.
Yoyok S, Aman MS. The effects of breathing exercise toward IgG, beta endorphin and blood glucose secretion. Asia Pac J Educ Arts Sci 2014;1:27-32. Available from: http://www.apjeas.apjmr.com. [Last accessed on 2015 Jan 07].  Back to cited text no. 10
    
11.
Silva F, Vinay H, Muninarayanappa NV. Effectiveness of deep breathing exercise (DBE) on the heart rate variability, BP, anxiety and depression of patients with coronary artery disease. NUJHS 2014;4:55-65. Available from: http://www.nitte.edu.in. [Last accessed on 2015 Jan 13].  Back to cited text no. 11
    
12.
Dhruva A, Miaskowski C, Abrams D, Acree M, Cooper B, Goodman S, et al. Yoga breathing for cancer chemotherapy-associated symptoms and quality of life: Results of a pilot randomized controlled trial. J Altern Complement Med 2012;18:473-9.  Back to cited text no. 12
    
13.
Stanley R, Leither TW, Sindelir C. Benefits of a holistic breathing technique in patients on hemodialysis. Nephrol Nurs J 2011;38:149-52.  Back to cited text no. 13
    
14.
Sengul YS, Ozalevli S, Oztura I, Itil O, Baklan B. The effect of exercise on obstructive sleep apnea: A randomized and controlled trial. Sleep Breath 2011;15:49-56.  Back to cited text no. 14
    
15.
Prem V, Sahoo RC, Adhikari P. Effect of diaphragmatic breathing exercise on quality of life in subjects with asthma: A systematic review. Physiother Theory Pract 2013;29:271-7.  Back to cited text no. 15
    
16.
Busch V, Magerl W, Kern U, Haas J, Hajak G, Eichhammer P, et al. The effect of deep and slow breathing on pain perception, autonomic activity, and mood processing – An experimental study. Pain Med 2012;13:215-28.  Back to cited text no. 16
    
17.
Salaskar R. YOGA for Kidney Failure; July, 2013. Available from: http://eyogaguru.com. [Last accessed on 2015 Jan 06].  Back to cited text no. 17
    
18.
Weil A. The Art and Science of Breathing; 2014. Available from: https://www.drweil.com/health-wellness/balanced-living/meditation- inspiration/the-art-and-science-of-breathing. [Last accessed on 2015 Dec 03].  Back to cited text no. 18
    
19.
Guerra-Guerrero V, Sanhueza-Alvarado O, Cáceres-Espina M. Quality of life in people with chronic hemodialysis: Association with sociodemographic, medical-clinical and laboratory variables. Rev Lat Am Enfermagem 2012;20:838-46.  Back to cited text no. 19
    
20.
Kim JY, Kim B, Park KS, Choi JY, Seo JJ, Park SH, et al. Health-related quality of life with KDQOL-36 and its association with self-efficacy and treatment satisfaction in Korean dialysis patients. Qual Life Res 2013;22:753-8.  Back to cited text no. 20
    


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    Tables

  [Table 1], [Table 2], [Table 3]



 

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