Indian Journal of Palliative Care
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Year : 2003  |  Volume : 9  |  Issue : 1  |  Page : 8--13

Evaluation of the analgesic effect of salmon calcitonin in metastatic bone pain

Unit of Anaesthesiology, Institute Rotary Cancer Hospital All India Institute of Medical Sciences,New Delhi, India

Correspondence Address:
Sushma Bhatnagar
2 North Avenue, IIT, New Delhi, 110 016
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Source of Support: None, Conflict of Interest: None

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Aim: To evaluate the efficacy of calcitonin in controlling metastatic bone pain. Materials and methods: Patients with bone metastases, with a numerical pain score greater than 4 wererandomized to receive calcitonin 200 IU subcutaneously 6 hourly for 48 hours (n= 10) or normal saline placebo (n = 10) . The parameters measured were the 11-point numerical pain score, ECOG functional capacity score, morphine consumption in 24 hours, duration of pain in 24 hours and subjective assessment of efficacy of treatment by a blinded investigator. Results: There was a statistically significant decrease in pain score at 48 hours (2 vs 6) and 7 days (3 vs 6) in the calcitonin arm as compared to the control arm. The reduction in duration of pain (3 vs 13) and improvement in ECOG (1.5 vs 2.5) score were also statistically significant. Adverse effects were nausea in 5 patients and vomiting in 3 patients on the day of calcitonin administration. This was controlled with antiemetics. There was no significant change in serum calcium level in either group.


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Online since 1st October '05
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