Indian Journal of Palliative Care
Open access journal 
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size Users online: 286  
     Home | About | Feedback | Login 
  Current Issue Back Issues Editorial Board Authors and Reviewers How to Subscribe Advertise with us Contact Us Analgesic Prescription  
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7398    
    Printed274    
    Emailed2    
    PDF Downloaded246    
    Comments [Add]    

Recommend this journal

 

 RESEARCH
Year : 2003  |  Volume : 9  |  Issue : 1  |  Page : 8--13

Evaluation of the analgesic effect of salmon calcitonin in metastatic bone pain


Unit of Anaesthesiology, Institute Rotary Cancer Hospital All India Institute of Medical Sciences,New Delhi, India

Correspondence Address:
Sushma Bhatnagar
2 North Avenue, IIT, New Delhi, 110 016
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Aim: To evaluate the efficacy of calcitonin in controlling metastatic bone pain. Materials and methods: Patients with bone metastases, with a numerical pain score greater than 4 wererandomized to receive calcitonin 200 IU subcutaneously 6 hourly for 48 hours (n= 10) or normal saline placebo (n = 10) . The parameters measured were the 11-point numerical pain score, ECOG functional capacity score, morphine consumption in 24 hours, duration of pain in 24 hours and subjective assessment of efficacy of treatment by a blinded investigator. Results: There was a statistically significant decrease in pain score at 48 hours (2 vs 6) and 7 days (3 vs 6) in the calcitonin arm as compared to the control arm. The reduction in duration of pain (3 vs 13) and improvement in ECOG (1.5 vs 2.5) score were also statistically significant. Adverse effects were nausea in 5 patients and vomiting in 3 patients on the day of calcitonin administration. This was controlled with antiemetics. There was no significant change in serum calcium level in either group.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 1st October '05
Published by Wolters Kluwer - Medknow